MYL12A

  • Official Full Name

    myosin, light chain 12A, regulatory, non-sarcomeric

  • Overview

    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain,;such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments;(Iwasaki et al., 2001 (PubMed 11942626)).

  • Synonyms

    MYL12A;myosin, light chain 12A, regulatory, non-sarcomeric;myosin, light polypeptide, regulatory, non sarcomeric (20kD);myosin regulatory light chain 12A;MLCB;MRCL3;MRLC3;MYL2B;myosin regulatory light chain 3;nonsarcomeric;RLC;ML12A_HUMAN;MLC 2B;MLC-2B;Myosin regulatory light chain 2;Myosin regulatory light chain 2, nonsarcomeric;Myosin regulatory light chain MRCL3;Myosin regulatory light chain MRLC3;Myosin RLC;OTTHUMP00000162243;myosin, light polypeptide, regula

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • N-His-SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
MYL12A-1814H Recombinant Human MYL12A protein, GST-tagged E.coli Human GST 1-171 aa
MYL12A-843H Recombinant Human MYL12A protein, His-tagged E.coli Human His 1-171a.a.
MYL12A-28634TH Recombinant Human MYL12A, His-tagged E.coli Human His 171 amino acids
MYL12A-2921R Recombinant Rhesus monkey MYL12A Protein, His-tagged Mammalian Cells Rhesus macaque His
MYL12A-3606H Recombinant Human MYL12A, His-tagged E.coli Human His
MYL12A-3852R Recombinant Rat MYL12A Protein Mammalian Cells Rat His
MYL12A-5458H Recombinant Human Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric E.coli Human Non
MYL12A-6893C Recombinant Chicken MYL12A Mammalian Cells Chicken His
MYL12A-4030HCL Recombinant Human MYL12A 293 Cell Lysate HEK293 Human Non
MYL12A-2740R Recombinant Rhesus Macaque MYL12A Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MYL12A-2740R-B Recombinant Rhesus Macaque MYL12A Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MYL12A-3511R Recombinant Rat MYL12A Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
MYL12A-3511R-B Recombinant Rat MYL12A Protein Pre-coupled Magnetic Beads HEK293 Rat
MYL12A-4844H Recombinant Human MYL12A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
MYL12A-5323H Recombinant Human MYL12A protein, His-SUMO-tagged E.coli Human N-His-SUMO 1-171aa
MYL12A-5536H Recombinant Human MYL12A Protein, His-tagged E.coli Human His

    Involved Pathway

    MYL12A involved in several pathways and played different roles in them. We selected most pathways MYL12A participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology FGF10B,PEBP1,DUSP7,NR5A1,AP2A1,UNC5D,TCF12,RHOAE,DNM1,SCN4A
    Axon guidance GNAI2,EFNA2,RHOD,MARK3,RANBP9,Ntng2,EPHA5,NRG3,LRRC4,DUSP2
    Platelet activation PTGS1,TBXA2R,PRKG2,PLCB2,AKT1,ARHGAP35,COL27A1,LCP2,PIK3R2,MAPK12
    Muscle contraction TNNI1B,TCAP,DESMB,TMOD4,DMD,TMEM8C,SMYHC2,MYBPC2B,LMOD1,VIML
    EPH-Ephrin signaling EPHA10,EFNA1B,SHB,EFNB2A,EFNB3B,AP2A2,ACTR3,EFNA3B,ACTR2B,CLTB
    Ephrin signaling EPHB3A,EFNB2A,EFNB3,EFNB3B,SDCBP,EPHB4A,EFNB1,EPHB4B,EFNB2
    Leukocyte transendothelial migration ITGA4,NIPAL1,CLDN6,CLDN1,CLDN3,CLDN9,ITGAL,CLDN16,Itgam&Itgb2,CLDN4
    Focal adhesion PIK3CB,VAV1,FYNB,RAC3A,CAPN2B,PIK3CA,RAC1,ITGA4,FYNA,MYL2

    Protein Function

    MYL12A has several biochemical functions, for example, calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL12A itself. We selected most functions MYL12A had, and list some proteins which have the same functions with MYL12A. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DR1,FCER2,REG3A,MAP4K5,RAB11A,RBM8A,CHMP1A,GSPT2,ANXA9,TFG
    calcium ion binding CALM3,PCDH2AA1,EFCAB4A,CD69,SRI,GSNA,CDH16,EFCAB2,MAN1B1,PCDHGA11

    Interacting Protein

    MYL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL12A.

    IKBKE;GRB2;CIT;Cdc42bpa;PAK1;MYLK;CDC42BPA;Rock2;Cdc42bpb;CHUK;EIF1B;TNFRSF1A;MCC;VHL;ACTB;MAP3K3;TNIK

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