Recombinant Human MYO3A cell lysate

• Cat.No.: MYO3A-1160HCL

Specification

• Species: Human
• Tag: Non
• Description: The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: MYO3A myosin IIIA [ Homo sapiens ]
• Official Symbol: MYO3A
• Synonyms: MYO3A; myosin IIIA; deafness, autosomal recessive 30 , DFNB30; myosin-IIIa; DFNB30
• Gene ID: 53904
• mRNA Refseq: NM_017433
• Protein Refseq: NP_059129
• MIM: 606808
• UniProt ID: Q8NEV4
• Chromosome Location: 10p11.1
• Function: ADP binding; ATP binding; actin binding; actin-dependent ATPase activity; calmodulin binding; microfilament motor activity; microfilament motor activity; nucleotide binding; plus-end directed microfilament motor activity; protein kinase activity; protein serine/threonine kinase activity