MYO3A
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Official Full Name
myosin IIIA -
Overview
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. -
Synonyms
MYO3A;myosin IIIA;deafness, autosomal recessive 30 , DFNB30;myosin-IIIa;deafness, autosomal recessive 30;DFNB30
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYO3A-90H |
Active Recombinant Human MYO3A, GST-tagged
|
Sf9 Cells | Human | GST | 1-434 a.a. |
|
| MYO3A-11619Z | Recombinant Zebrafish MYO3A | Mammalian Cells | Zebrafish | His |
|
|
| MYO3A-1160HCL | Recombinant Human MYO3A cell lysate | Human | Non |
|
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| MYO3A-301341H | Recombinant Human MYO3A protein, GST-tagged | E.coli | Human | GST | Gln1090-Ser1308 |
|
| MYO3A-5838H | Recombinant Human MYO3A Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| MYO3A-6774HF | Recombinant Full Length Human MYO3A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 247 amino acids |
|
Involved Pathway
MYO3A involved in several pathways and played different roles in them. We selected most pathways MYO3A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MYO3A has several biochemical functions, for example, ADP binding,ATP binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO3A itself. We selected most functions MYO3A had, and list some proteins which have the same functions with MYO3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MAPKAPK5,CNGA2,EWSR1,MAPKAPK2A,AKAP5,DDX5,MYH10,EEA1,ADCY3,STRN4 |
| plus-end directed microfilament motor activity | MYO19 |
| protein serine/threonine kinase activity | SGK2B,ADCK4,TLK1B,SRPK2,MAPK12A,DYRK2,RIPK2,MAPK14,TBK1,SMOK3A |
| actin filament binding | EZR,ACTN2B,MYO6,FSCN2A,VCLA,TMOD4,GAS7,PKNOX2,SVIL,HIST1H2AH |
| protein kinase activity | CCL8,LIMK1A,RIPK3,ANKK1,CLK2A,Fert2,CSF1RA,RBM4.3,MAP2K4A,RAF1B |
| ATP binding | CHD4A,LRGUK,KIF5AA,ACTC1A,UBE2IA,MAP2K6,DDX24,MAPK8B,ATP2B1B,CHTF18 |
| actin-dependent ATPase activity | MYO1D,MYO1C,MYH9,MYH7,MYH10,MYL6,MYO7A |
| microfilament motor activity | MYH10,MYH9,MYO5B,MYO1D,MYO1E,MYO9B,MYH7,MYO3B,MYO7A,MYH8 |
| ADP binding | PRPS1,ATP1A1,APAF1,MYO7A,HSP104,MYH9,CHORDC1,ME1,GLUD2,VCP |
Interacting Protein
MYO3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO3A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO3A.
GRINL1A
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