Recombinant Human MXI1 Protein, GST-His-tagged

• Cat.No.: MXI1-746H
• Product Overview: Recombinant Human MXI1, transcript variant 3, fused with N-terminal GST and C-terminal His was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His&GST
• Description: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 48.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: MXI1 MAX interactor 1 [ Homo sapiens ]
• Official Symbol: MXI1
• Synonyms: MXI1; MAX interactor 1; MAX interacting protein 1; max-interacting protein 1; bHLHc11; MAD2; MXD2; MXI; MAX dimerization protein 2; Max-related transcription factor; class C basic helix-loop-helix protein 11; MGC43220
• Gene ID: 4601
• mRNA Refseq: NM_001008541
• Protein Refseq: NP_001008541
• MIM: 600020
• UniProt ID: P50539