Recombinant Human MUTYH Protein, His-tagged

• Cat.No.: MUTYH-106H
• Product Overview: Recombinant Human MUTYH, transcript variant alpha1, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 59.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: MUTYH mutY homolog (E. coli) [ Homo sapiens ]
• Official Symbol: MUTYH
• Synonyms: MUTYH; mutY homolog (E. coli); mutY (E. coli) homolog; A/G-specific adenine DNA glycosylase; MYH; CYP2C; MGC4416
• Gene ID: 4595
• mRNA Refseq: NM_012222
• Protein Refseq: NP_036354
• MIM: 604933
• UniProt ID: Q9UIF7