Recombinant Human MLLT3 protein, GST-tagged

• Cat.No.: MLLT3-264H
• Product Overview: Recombinant Human MLLT3(1-149 aa)(YEATS DOMAIN) fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-149 a.a.
• Description: The AF9 protein is part of the super elongation complex and also associates with the histone methyltransferase DOT1L. Translocation of the AF9 gene to the MLL gene, resulting in an MLL/AF9 fusion is the most common chromosomal rearrangement involving MLL in de novo AML. The YEATS domain of binds strongly to histone H3K9 acetylation and, to a lesser extent, H3K27 and H3K18 acetylation.
• Form: Recombinant protein at 1 mg/ml in 50 mM HEPES pH 7.3, 200 mM NaCl, 1 mM DTT, 10% glycerol.
• Molecular Mass: 41 kDa
• Applications: AF9 YEATS Domain, Recombinant Human is useful for protein binding and screening experiments examining acetylated protein substrates.
• Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 [ Homo sapiens ]
• Official Symbol: MLLT3
• Synonyms: MLLT3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3; protein AF-9; AF 9; AF9; YEATS3; YEATS domain-containing protein 3; ALL1-fused gene from chromosome 9 protein; myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3; FLJ2035
• Gene ID: 4300
• mRNA Refseq: NM_004529
• Protein Refseq: NP_004520
• MIM: 159558
• UniProt ID: P42568
• Chromosome Location: 9p22
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem