MLLT3
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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) -
Overview
Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein. -
Synonyms
MLLT3;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 3;AF9;YEATS3;protein AF-9;YEATS domain-containing protein 3;ALL1-fused gene from chromosome 9 protein;myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog);translocated to, 3
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&B2M
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MLLT3-908H | Recombinant Human MLLT3, GST-tagged | E.coli | Human | GST | N-term-348aa | |
| MLLT3-2550Z | Recombinant Zebrafish MLLT3 | Mammalian Cells | Zebrafish | His |
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| MLLT3-264H | Recombinant Human MLLT3 protein, GST-tagged | E.coli | Human | GST | 1-149 a.a. |
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| MLLT3-265H | Recombinant Human MLLT3 protein, GST-tagged | E.coli | Human | GST | 1-149 a.a. |
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| MLLT3-266H | Recombinant Human MLLT3 protein, GST-tagged | E.coli | Human | GST | 1-149 a.a. |
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| MLLT3-580H | Recombinant Human MLLT3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| MLLT3-9887M | Recombinant Mouse MLLT3 Protein | Mammalian Cells | Mouse | His |
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| MLLT3-4292HCL | Recombinant Human MLLT3 293 Cell Lysate | HEK293 | Human | Non |
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| MLLT3-2384H | Recombinant Human MLLT3 protein, His-B2M-tagged | E.coli | Human | His&B2M | 1-568aa |
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| MLLT3-294H | Recombinant Human MLLT3 protein, His-tagged | E.coli | Human | His | 574aa |
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| Mllt3-4092M | Recombinant Mouse Mllt3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MLLT3-5392H | Recombinant Human MLLT3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MLLT3-5586M | Recombinant Mouse MLLT3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MLLT3-5586M-B | Recombinant Mouse MLLT3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MLLT3-6365HF | Recombinant Full Length Human MLLT3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 568 amino acids |
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Involved Pathway
MLLT3 involved in several pathways and played different roles in them. We selected most pathways MLLT3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLLT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | BCL2A1,PBX1,PPARG,MEF2C,BIRC3,EWSR1,RXRA,BCL2L1,MAF,SSX2 |
Protein Function
MLLT3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLLT3 itself. We selected most functions MLLT3 had, and list some proteins which have the same functions with MLLT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ITCH,RPS11,HIF1AN,KNG1,ALKBH3,DNAJB11,GNG10,MRPL41,CSTF3,HSPA4 |
Interacting Protein
MLLT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLLT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLLT3.
DOT1L;CDK9;AFF4;CCNT1;ELL2;MLLT1
Resources
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References
- Zhang, WZ; Yu, ZY; et al. An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the alpha ENaC gene. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 304:F367-F375(2013).
