Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, His-tagged

• Cat.No.: MAP3K10-1256H
• Product Overview: Recombinantfull-length human MAP3K10 with N-terminal His tag is expressed in Sf9 insectcells.

Specification

• Cat. No.: MAP3K10-1256H
• Description: The protein encodedby this gene is a member of the serine/threonine kinase family. This kinasehas been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itselfcan be phoshorylated, and thus activated by JNK kinases. This kinasefunctions preferentially on the JNK signaling pathway, and is reported to beinvolved in nerve growth factor (NGF) induced neuronal apoptosis.
• Source: Sf9 insect cells
• Species: Human
• Form: Liquid in50 mM sodium phosphate, pH 7.0 + 300 mM NaCl + 150 mM imidazole + 0.1 mM PMSF+ 0.2 mM DTT + 25% glycerol.
• Molecular Weight: ~ 47 kDa
• Purity: > 90% bydensitometry.
• Concentration: 0.2 mg/ml
• Storage: Centrifugevial prior to opening. Store product at -80°C. For optimal storage, aliquot targetinto smaller quantities and store at recommended temperature. Avoid repeated freeze-thawcycles.
• OfficialSymbol: MAP3K10
• Function: ATP binding; JUNkinase kinase kinase activity; bHLH transcription factor binding; protein homodimerizationactivity; protein kinase activity; transcription corepressor activity; nucleotidebinding; protein serine/tyreonine kinase activity

Gene Information

• Gene Name: MAP3K10 mitogen-activatedprotein kinase kinase kinase 10 [ Homo sapiens ]
• Synonyms: MAP3K10; mitogen-activatedprotein kinase kinase kinase 10; MST; MLK2; MEKK10; mixed lineage kinase 2;MKN28 derived nonreceptor type serine/threonine kinase; MKN28 kinase; proteinkinase MST; EC 2.7.11.25
• Gene ID: 4294
• mRNA Refseq: NM_002446
• Protein Refseq: NP_002437
• MIM: 600137
• UniProt ID: Q02779
• Chromosome Location: 19q13.2
• Pathway: Insulin Signaling;p38 MARK signaling pathway