Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged

• Cat.No.: MAPK11-1134H
• Product Overview: Recombinant full-length human p38 beta was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: MAPK11 is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress. The MAPK11 is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. Alternatively spliced transcript variants encoding the same protein have been observed.
• Specific Activity: The specific activity of MAPK11 was determined to be 123 nmol /min/mg as per activity assay protocol.
• Molecular Weight: 71.0 kDa
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, and 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Appearance: Liquid
• Purity: ≥90% by SDS-PAGE
• Storage: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MAPK11 mitogen-activated protein kinase 11 [ Homo sapiens ]
• Official Symbol: MAPK11
• Synonyms: MAPK11; mitogen-activated protein kinase 11; P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2; mitogen-activated protein kinase 11;MAPK 11; MAP kinase 11; OTTHUMP00000196653; OTTHUMP00000196655; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase-2b; mitogen-activated protein kinase p38-2; mitogen-activated protein kinase p38 beta; EC=2.7.11.24
• Gene ID: 5600
• mRNA Refseq: NM_002751
• Protein Refseq: NP_002742
• MIM: 602898
• UniProt ID: Q15759
• Chromosome Location: 22q13.33
• Pathway: ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors; Amyotrophic lateral sclerosis (ALS); CD40/CD40L signaling; CXCR3-mediated signaling events; DSCAM interactions; Dopaminergic synapse; FAS (CD95) signaling pathway; GnRH signaling pathway; Influenza A; Metabolism of mRNA; Pertussis; Toll Like Receptor 5 (TLR5) Cascade; VEGF signaling pathway
• Function: ATP binding; MAP kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity