MAPK11

  • Official Full Name

    mitogen-activated protein kinase 11
  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms

    MAPK11;mitogen-activated protein kinase 11;PRKM11;p38 2;p38Beta;SAPK2;MAPK 11;MAP kinase 11;MAP kinase p38 beta;stress-activated protein kinase 2;stress-activated protein kinase-2;stress-activated protein kinase 2b;stress-activated protein kin

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • Human
  • HEK293
  • Insect Cells
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli Human GST
MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Cells Human GST
MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cells Chicken His
MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli Human His 364 amino acids
MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli Human His
MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cells Zebrafish His
MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Cells Human GST
MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli Human Non Full L. 38-b a.a.
MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human Human His
MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cells Mouse His
MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 Human Non
MAPK11-1084H Recombinant Human MAPK11 Protein (S2-Q364), Tag Free Insect Cells Human Non S2-Q364
MAPK11-1085H Recombinant Human MAPK11 Protein (S2-Q364), GST tagged Insect Cells Human GST S2-Q364
MAPK11-2038HF Active Recombinant Full Length Human MAPK11 Protein, GST-tagged E.coli Human GST Full L. 1-364
Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MAPK11-4996H Recombinant Human MAPK11 Protein (Leu24-Phe308), N-His tagged E.coli Human His Leu24-Phe308
MAPK11-5344M Recombinant Mouse MAPK11 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MAPK11-5344M-B Recombinant Mouse MAPK11 Protein Pre-coupled Magnetic Beads HEK293 Mouse
MAPK11-7755H Recombinant Human MAPK11 protein, His-tagged E.coli Human His 379aa(including fusion tag)

    Involved Pathway

    MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway,Rap signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopaminergic synapse GNB3,PPP2R2B,CALY,GNG13,SLC18A1,CALM1,KCNJ3,GNG12,CALML3,CAMK2D
    Sphingolipid signaling pathway ACER1,ASAH1,NFKB1,GAB2,MAPK13,RAC2,S1PR4,MAPK12,NRAS,MAP2K2
    Chagas disease (American trypanosomiasis) CD247,IKBKB,NOS2,SMAD2,PLCB4,MAPK3,CXCL8,TGFBR2,PPP2R1B,C3
    GnRH signaling pathway CALM1,RAF1,CACNA1C,MMP14A,GRB2B,PRKACBA,CAMK2G1,CALM3B,PRKACB,CALML5
    Leukocyte transendothelial migration PLCG1,CLDN9,CDH5,CYBB,RAC2,CLDN4,PRKCB,ACTN1,NCF2,ROCK1
    TNF signaling pathway PIK3CB,CASP10,TNF,RPS6KA4,MAPK1,NFKB1,CXCL5,BAG4,FAS,ITCH
    T cell receptor signaling pathway AKT2,MAPK13,LCP2,PTPN6,AKT1,NFKBIB,CD40LG,VAV1,CD8B,IKBKB
    Rap signaling pathway PRKCI,RAC3,ANGPT2,FGF5,THBS1,INS2,GNAQ,MAPK12,FPR1,PGF
    Toll-like receptor signaling pathway CXCL9,PIK3R3A,TICAM2,TRAF3,TNF,TRAF6,MAPK9,STAT1B,MAP3K7,TLR5

    Protein Function

    MAPK11 has several biochemical functions, for example, ATP binding,MAP kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine kinase activity NEK6,NEK12,ILK,PLK2B,SLK,TSSK6,STK24,PAK3,NEK1,PRPF4B
    protein binding COL18A1,ADIPOQ,TRIM15,SERPINB9,KLF17,P2RY6,DULLARD,OFCC1,ADRB2,ERRFI1
    ATP binding MAP3K1,CHD4,CKM,TK1,CKMT2,MERTK,KIAA1804,ADCK2,TEP1,TAOK2
    MAP kinase activity MAPK8A,MAPK12A,MAPK8B,MAPK13,NLK,MAPK14B,MAPK14,NLK1,NLK2,MAPK15

    Interacting Protein

    MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.

    MAPK14;MAPKAPK3;ZNHIT1;TP53;ATF2;ATF2;TAB1;SOCS3;CPNE6;POLR3D;C9orf78;OBSL1;KRT1;SP1;MYB;VARS

    MAPK11 Related Signal Pathway

    Resources

    References

    • Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    • Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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