MAPK11
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Official Full Name
mitogen-activated protein kinase 11 -
Overview
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase. -
Synonyms
MAPK11;mitogen-activated protein kinase 11;PRKM11;p38 2;p38Beta;SAPK2;MAPK 11;MAP kinase 11;MAP kinase p38 beta;stress-activated protein kinase 2;stress-activated protein kinase-2;stress-activated protein kinase 2b;stress-activated protein kin
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- Human
- HEK293
- Insect Cells
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway,Rap signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | GABRB3,PLCB2,GNAQ,PRKACG,GABRR2,GNG2,NAPEPLD,ITPR1,GRIA3,ITPR3 |
| Chagas disease (American trypanosomiasis) | PPP2R2C,CD247,C1QC,PIK3R1,GNAI2,PPP2R1A,PPP2CB,MAPK3,PLCB2,MAPK12 |
| Rap signaling pathway | GNAI1,CALM4,FGFR3,FGFR1,PARD3,VEGFA,PIK3CG,RAC3,PRKD2,ITGB2 |
| Signaling pathways regulating pluripotency of stem cells | LIF,LHX5,FZD9,WNT6,INHBC,STAT3,WNT8B,SOX2,PIK3R2,PIK3CA |
| MAPK signaling pathway | MRAS,MAP3K13,RAP1B,MAP3K4,FGFR2,MAPK4,NFKB1,NTF4,IKBKG,SRFA |
| Proteoglycans in cancer | TRP53,MRAS,SRC,ANK1,SMO,RAC1,PIK3R3,GPC3,PRKACB,RRAS2 |
| Amyotrophic lateral sclerosis (ALS) | NEFL,DAXX,BCL2,NEFM,TOMM40,GRIN2B,CAT,TRP53,TP53,NEFH |
| Leishmaniasis | IL12B,IFNGR2,TLR2,CR1,HLA-DQA2,HLA-DOA,PTGS2,IL1A,C3,IL4 |
| Inflammatory mediator regulation of TRP channels | CALML3,ASIC4,CYP2C70,PLA2G4A,TRPV4,GNAQ,HTR2A,PIK3R1,TRPM8,IL1B |
Protein Function
MAPK11 has several biochemical functions, for example, ATP binding,MAP kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase activity | NLK2,MAPK12A,MAPK12B,MAPK12,MAPK1,MAPK6,MAPK14A,MAPK14B,MAPK14,MAPK3 |
| protein serine/threonine kinase activity | AURKA,PAK2B,UHMK1,TNNI3K,PRKCQ,SYK,ADCK4,AKT3,NEK8,LRRK1 |
| ATP binding | KIF21A,GSG2,DDX19,JAK2,ERCC6L,ACSF3,DCAKD,NLRP9C,LRRK2,NAT1 |
| protein binding | KRT14,CXCL14,PTPN11,REL,SLC30A1,MED22,CA8,CNPY2,FYCO1,WT1 |
Interacting Protein
MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14;MAPKAPK3;ZNHIT1;TP53;ATF2;ATF2;TAB1;SOCS3;CPNE6;POLR3D;C9orf78;OBSL1;KRT1;SP1;MYB;VARS
MAPK11 Related Signal Pathway
Resources
Research Area
Apoptosis Intracellular KinasesDiabetic Peripheral Neuropathy
Intracellular Kinases in the Akt Pathway
p38 MAP Kinases
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
Related Services
Related Products
References
- Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
- Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
