Recombinant Human MINK1, GST-tagged, Active

• Cat.No.: MINK1-354H
• Product Overview: Recombinant human MINK1 (1-320) was expressed by baculovirus inSf9insect cells using a N-terminal GST tag. MW = 61 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-320 a.a.
• Description: MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival. Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway.
• Sequence: 1-320.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MINK1 misshapen-like kinase 1 (zebrafish) [ Homo sapiens ]
• Synonyms: MINK1; misshapen-like kinase 1 (zebrafish); B55; ZC3; MINK; YSK2; hMINK; MAP4K6; MGC21111; hMINKbeta; GCK family kinase MINK; misshapen/NIK-related kinase; serine/threonine protein kinase; EC 2.7.11.1; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Mitogen-activated protein kinase kinase kinase kinase 6; misshapen-like kinase 1 (zebrafish)
• Gene ID: 50488
• mRNA Refseq: NM_001024937
• Protein Refseq: NP_001020108
• MIM: 609426
• UniProt ID: Q8N4C8
• Chromosome Location: 17p13.2
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity; transferase activity