MINK1
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Official Full Name
misshapen-like kinase 1 -
Overview
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. -
Synonyms
MINK1;misshapen-like kinase 1;misshapen like kinase 1 (zebrafish);B55;MAP4K6;MINK;misshapen/NIK related kinase;YSK2;ZC3;MEKKK 6;MEK kinase kinase 6;GCK family kinase MINK;misshapen/NIK-related kinase;MAPK/ERK kinase kinase kinase 6;serine/th
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MINK1-1431H |
Active Recombinant Human MINK1, GST-tagged
|
Sf9 Cells | Human | GST | 1-320 aa |
|
| MINK1-354H | Recombinant Human MINK1, GST-tagged, Active | Sf9 Cells | Human | GST | 1-320 a.a. |
|
| MINK1-5455H | Recombinant Human Misshapen-Like Kinase 1 (zebrafish), GST-tagged | Insect Cells | Human | GST | 1-320 a.a. |
|
| MINK1-5640Z | Recombinant Zebrafish MINK1 | Mammalian Cells | Zebrafish | His |
|
|
| MINK1-1078H | Recombinant Human MINK1 Protein (M1-G314), Tag Free | Insect Cells | Human | Non | M1-G314 |
|
| MINK1-1079H | Recombinant Human MINK1 Protein (M1-G314), GST tagged | Insect Cells | Human | GST | M1-G314 |
|
| MINK1-1353H | Recombinant Human MINK1 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
|
|
| MINK1-3624H | Recombinant Human MINK1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
|
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| Mink1-4075M | Recombinant Mouse Mink1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
|
| MINK1-5342H | Active Recombinant Human MINK1 Protein, GST/His-tagged | Insect Cells | Human | GST&His |
|
Involved Pathway
MINK1 involved in several pathways and played different roles in them. We selected most pathways MINK1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MINK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | H3F3D,POT1,HIST1H1B,CDKN2C,NUP35,SCMH1,HSBP1A,WDR45,EPAS1B,HDAC6 |
| Insulin Signaling | MAP4K5,INPP4AA,SGK2,STXBP3,STXBP2,MAP4K1,CAP1,ARHGAP33,EHD1,GSK3AB |
| MAPK signaling pathway | FGFR2,CACNA1B,PLA2G4AA,FGF20B,IL1A,PRKCBA,FLNA,TAOK3,MAPK8,CACNA1C |
| Cellular Senescence | CBX8B,HMGA1B,TNIK,BMI1B,HIST3H2BB,ASF1A,RBBP4,RNF2,E2F2,POT1 |
| Oxidative Stress Induced Senescence | SCMH1,TNIK,BMI1B,CBX4,CBX8B,SUZ12B,RING1,PHC3,SUZ12A,PHC1 |
Protein Function
MINK1 has several biochemical functions, for example, ATP binding,NOT MAP kinase kinase kinase kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MINK1 itself. We selected most functions MINK1 had, and list some proteins which have the same functions with MINK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | PIM3,SBK1,GAK,MAPKAPK2,CAMK1GA,STK38,PRKDC,ACVR2A,MYO3A,ADCK4 |
| NOT MAP kinase kinase kinase kinase activity | TNIK,NRK,TNIKA,TNIKB,MAP4K4 |
| ATP binding | RAD51,PIP4K2B,ARAF,STK19,ACLYA,UBE2A,MAP2K4B,C10orf2,CDK15,FAM20B |
| protein binding | APPL1,ZMYND11,COMMD9,C9orf24,C11orf54,RNF216,RAB39B,C1orf50,NCBP2,MIS18BP1 |
| protein kinase activity | BMPR1BA,CHEK1,NEK4,DCLK3,PIK3CG,WEE2,RIPK4,BMPR1AB,WNK2,MAPKAPK2B |
Interacting Protein
MINK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MINK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MINK1.
HSF1;IER5;abl-tide;MAP4K4;HSP90AB1;RAP2A
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References
- Mathivanan, S; Lim, JWE; et al. Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature. MOLECULAR & CELLULAR PROTEOMICS 9:197-208(2010).
