Recombinant Human microfibrillar-associated protein 2, His-tagged

• Cat.No.: MFAP2-342H
• Product Overview: MFAP2, 18-183aa, Human, His tag, E.coli

Specification

• Description: Microfibrillar-associated protein 2, also known as MFAP2, is an O-glycosylated protein secreted to the extracellular space and the extracellular matrix. MFAP2 associates with biglycan and elastin in a ternary complex. It is shown to play a significant role in the support and distensibility of the juxtacanalicular region of these collector channels. It is also reported to inhibit LTB-1 binding to fibrillin-1, stimulate the phosphorylation of Smad2, and thereby mediate the subsequent extracellular deposition of latent TGFbeta. Recombinant human MFAP2, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1M Urea, 20% glycerol
• Molecular Mass: 21.5 kDa (190aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMQGQYDL DPLPPFPDHV QYTHYSDQID NPDYYDYQEV TPRPSEEQFQ FQSQQQVQQE VIPAPTPEPG NAELEPTEPG PLDCREEQYP CTRLYSIHRP CKQCLNEVCF YSLRRVYVIN KEICVRTVCA HEELLRADLC RDKFSKCGVM ASSGLCQSVA ASCARSCGSC
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Protein length: 18-183 a.a.

Gene Information

• Gene Name: MFAP2 microfibrillar-associated protein 2 [ Homo sapiens ]
• Official Symbol: MFAP2
• Synonyms: MFAP2; microfibrillar-associated protein 2; MAGP; MAGP 1; microfibril-associated glycoprotein 1; MAGP1; MAGP-1; FLJ50901
• Gene ID: 4237
• mRNA Refseq: NM_001135247
• Protein Refseq: NP_001128719
• MIM: 156790
• UniProt ID: P55001
• Chromosome Location: 1p36.1-p35
• Pathway: Notch signaling pathway, organism-specific biosystem
• Function: fibrinogen binding; fibronectin binding