Recombinant Human MERTK Protein, Fc\Avi-tagged

• Cat.No.: MERTK-175H
• Product Overview: Biotinylated Recombinant Human MerTK (C-hFc-Avi) is produced by Human Cells. The target gene encoding Arg26-Ala499 is expressed with a C-hFc-Avi tag.

Specification

• Species: Human
• Source: Human Cells
• Tag: Avi&Fc
• Protein Length: 26-499 a.a.
• Description: Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Form: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• AA Sequence: Arg26-Ala499
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: MERTK MER proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: MERTK
• Synonyms: MER; RP38; c-Eyk; c-mer; Tyro12
• Gene ID: 10461
• mRNA Refseq: NM_006343.3
• Protein Refseq: NP_006334.2
• MIM: 604705
• UniProt ID: Q12866