Recombinant Human MCOLN3 Protein (A2-K533), MBP tagged

• Cat.No.: MCOLN3-0771H
• Product Overview: Recombinant Human N-MBP-3C-TEV-TRPML3 (A2-K533 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: MBP
• ProteinLength: A2-K533
• Description: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Formulation:
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: MCOLN3 mucolipin 3 [ Homo sapiens (human) ]
• Official Symbol: MCOLN3
• Synonyms: MCOLN3; mucolipin 3; mucolipin-3; FLJ11006; TRP ML3; TRPML3; TRP-ML3; FLJ36629; MGC71509
• Gene ID: 55283
• mRNA Refseq: NM_001253693
• Protein Refseq: NP_001240622
• MIM: 607400
• UniProt ID: Q8TDD5