Recombinant Human MCAM

• Cat.No.: MCAM-27836TH
• Product Overview: Recombinant full length protein of Human CD146 with proprietary tag; predicted MW 97.17 kDa, inclusive of tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 646 amino acids
• Description: CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage.
• Molecular Weight: 97.170kDa inclusive of tags
• Tissue specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progress
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEV GSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQ GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSG LYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPP HFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE AGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKV WVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLT TLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGV VIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEK YIDLRH
• Sequence Similarities: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Gene Information

• Gene Name: MCAM melanoma cell adhesion molecule [ Homo sapiens ]
• Official Symbol: MCAM
• Synonyms: MCAM; melanoma cell adhesion molecule; cell surface glycoprotein MUC18; CD146; Gicerin; MUC18
• Gene ID: 4162
• mRNA Refseq: NM_006500
• Protein Refseq: NP_006491
• MIM: 155735
• Uniprot ID: P43121
• Chromosome Location: 11q23.3