MCAM
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Official Full Name
melanoma cell adhesion molecule -
Overview
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration. -
Synonyms
MCAM;melanoma cell adhesion molecule;cell surface glycoprotein MUC18;CD146;Gicerin;MUC18;melanoma adhesion molecule;cell surface glycoprotein P1H12;melanoma-associated antigen A32;melanoma-associated antigen MUC18;S-endo 1 endothelial-associated antigen
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Cynomolgus
- HEK293
- Human Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- Human Cells
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- Fc
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
MCAM involved in several pathways and played different roles in them. We selected most pathways MCAM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MCAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MCAM has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MCAM itself. We selected most functions MCAM had, and list some proteins which have the same functions with MCAM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
MCAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCAM here. Most of them are supplied by our site. Hope this information will be useful for your research of MCAM.
gd3;ATF7IP;UBE2O;CD9
Resources
Research Area
Endothelial Cell MarkersMyogenesis Markers
Immunoglobulin Superfamily CAMs
Endothelial Cell Differentiation Markers
Osteogenesis Markers
Adipose-derived Stem Cell Markers
CD Antigen (Dendritic Cell Adhesion)
Osteoprogenitor Markers
Skeletal Muscle Markers
Dendritic Cell Adhesion and Migration
Melanoma Biomarkers
Related Services
Related Products
References
- Lei, X; Guan, CW; et al. The multifaceted role of CD146/MCAM in the promotion of melanoma progression. CANCER CELL INTERNATIONAL 15:-(2015).
- Iwata, M; Torok-Strob, B; et al. CDCP1 Identifies a CD146 Negative Subset of Marrow Fibroblasts Involved with Cytokine Production. PLOS ONE 9:-(2014).
