Recombinant Human MARK3, GST-tagged, Active

• Cat.No.: MARK3-349H
• Product Overview: Recombinant full-length human MARK3 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 110 kDa.

Specification

• Cat. No.: MARK3-349H
• Description: Microtubule affinity-regulating kinase 3 (MARK3) is a member of the PAR-1/MARK kinase family which play critical roles in polarity and cell cycle control and are regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC). MARK3 is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating CDC2. MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: MARK3 MAP/microtubule affinity-regulating kinase 3 [ Homo sapiens ]
• Synonyms: MARK3; MAP/microtubule affinity-regulating kinase 3; KP78; CTAK1; PAR1A; EC 2.7.11.1; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Serine/threonine-protein kinase p78
• Gene ID: 4140
• mRNA Refseq: NM_001128918
• Protein Refseq: NP_001122390
• MIM: 602678
• UniProt ID: P27448
• Chromosome Location: 14q32.3
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity