Recombinant Human MAP3K14

• Cat.No.: MAP3K14-30381TH
• Product Overview: Recombinant Fragment from Human MAP3K14

Specification

• Description: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
• Tissue specificity: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
• Biological activity: The protein has a GST tag.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.
• Tag: Non

Gene Information

• Gene Name: MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens ]
• Official Symbol: MAP3K14
• Synonyms: MAP3K14; mitogen-activated protein kinase kinase kinase 14; FTDCR1B; HS; HSNIK; NIK; serine/threonine protein kinase
• Gene ID: 9020
• mRNA Refseq: NM_003954
• Protein Refseq: NP_003945
• MIM: 604655
• Uniprot ID: Q99558
• Chromosome Location: 17q21-q22
• Pathway: Adaptive Immune System, organism-specific biosystem; Alternative NF-kappaB pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; CD28 co-stimulation, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding