MAP3K14
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Official Full Name
mitogen-activated protein kinase kinase kinase 14 -
Overview
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. -
Synonyms
MAP3K14;mitogen-activated protein kinase kinase kinase 14;FTDCR1B;HS;HSNIK;NIK;serine/threonine protein kinase;NF-kappa-beta-inducing kinase;serine/threonine protein-kinase;serine/threonine-protein kinase NIK
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Strep
- Avi
- Fc
- Myc
Involved Pathway
MAP3K14 involved in several pathways and played different roles in them. We selected most pathways MAP3K14 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Intestinal i | MHC2A,CD86,CD28,CD40,AICDA,ITGB7,CCR10,CXCL12B,HLA-DMA,CXCR4 |
| HTLV-I infection | PDGFRB,PDGFA,NFATC4,TGFB1,CD3D,H2-Q10,WNT2B,HLA-E,HLA-DPA1,DVL1 |
| T cell receptor signaling pathway | NRAS,NCK2,CD40LG,MAPK11,MAP2K7,PAK7,FOS,CABIN1,AKT1,PTPRC |
| MAPK signaling pathway | RAP1B,ARRB1,MAPK11,ELK4,RAC3B,MAPKAPK3,RPS6KA5,RAC1A,FGF7,PPP5C |
| Epithelial cell signaling in Helicobacter pylori infection | PTPN11,CDC42,ATP6V1F,ATP6V1H,ATP6V1C1,IKBKG,LYN,PLCG1,JAM3,NFKB1 |
| Epstein-Barr virus infection | HLA-A,EIF2AK1,YWHAB,NEDD4,PSMD6,POLR3GL,SYK,CD19,PSMD8,POLR2A |
| Apoptosis | DSG1,DCC,DIABLO,TRP53,CASP10,AKT2,PPP3CC,CASP8,SPNA2,CASP12 |
| TNF signaling pathway | TNFRSF1B,TNFAIP3,MAPK3,PIK3CB,TRAF5,TRAF3,IL18R1,TRAF2,NFKB1,CREB3L1 |
| NF-kappa B signaling pathway | CCL21,ZAP70,BCL2,CD40,TICAM2,BCL2A1A,PIAS4,IKBKB,IL1B,DDX58 |
Protein Function
MAP3K14 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K14 itself. We selected most functions MAP3K14 had, and list some proteins which have the same functions with MAP3K14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | CDK16,CLK3,CPNE3,TP53RK,MAP4K4,NUAK2,ADCK4,FASTK,NLK2,TAOK2 |
| MAP kinase kinase kinase activity | MAP3K12,MAP3K8,ZAK,KIAA1804,BRAF,STK4,MAP3K3,MAP3K4,YSK4,MAP3K6 |
| ATP binding | MARS,MTHFD1,CKM,GMPS,DNAJA3B,MYO3B,SMARCA5,NIM1K,SPO11,TGFBR1A |
| protein kinase activity | STK26,MAP2K2A,MAP2K4,TRIO,ERBB3B,SRPK1A,PRKG1A,MAPK14B,PKN3,EIF2AK2 |
| protein binding | ZNF18,FRMD5,CXADR,MCL1,NITR9,TEX10,AGR3,STK11,YAP1,KRTAP12-4 |
| MAP kinase kinase activity | MAP2K2B,ALPK2,MAP3K20,MAP2K3,MAP2K2,PAK3,MAPK10,SBK3,MAPK14,LRRK2 |
| NF-kappaB-inducing kinase activity | ALPK2,PPP4C,IRAK1,RIPK3,IKBKE,ALK |
Interacting Protein
MAP3K14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K14.
CHUK;IKBKB;ALPL;HSP90AB1;CDC37;TRAF6
MAP3K14 Related Signal Pathway
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