Recombinant Human MAP2K3, His-tagged

• Cat.No.: MAP2K3-794H
• Product Overview: Recombinant human MAP2K3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.(1-318aa)

Specification

• Cat. No.: MAP2K3-794H
• Description: MAP2K3, also known as dual specificity mitogen-activated protein kinase kinase 3, is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS
• Formulation: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
• Purity: 90% by SDS - PAGE
• Molecular Weight: 38.3 kDa (338aa), confirmed by MALDI-TOF
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: MAP2K3 mitogen-activated protein kinase kinase 3 [ Homo sapiens ]
• Synonyms: MEK3; MKK3; MAPKK3; MAP2K3; MAP kinase kinase 3;PRKMK3;EC 2.7.12.2; dual specificity mitogen-activated protein kinase kinase 3; mitogen activated protein kinase kinase 3; OTTHUMP00000166044; MAPK/ERK kinase 3
• Gene ID: 5606
• mRNA Refseq: NM_002756
• Protein Refseq: NP_002747
• MIM: 602315
• UniProt ID: P46734
• Chromosome Location: 17q11.2
• Function: ATP binding; MAP kinase kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity