MAP2K3
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Official Full Name
mitogen-activated protein kinase kinase 3 -
Overview
MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP -
Synonyms
MAP2K3;mitogen-activated protein kinase kinase 3;PRKMK3;dual specificity mitogen-activated protein kinase kinase 3;dual specificity mitogen activated protein kinase kinase 3;MAP kinase kinase 3;MAPK/ERK kinase 3;MAPKK3;MEK3;MKK3;MEK 3;MAPKK 3
Recombinant Proteins
- Chicken
- Rhesus macaque
- Human
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Insect cells
- HEK293T
- Insect (sf21)
- His
- His&MBP
- Non
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- MBP&His&Avi
Involved Pathway
MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway,Rap signaling pathway,Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FYB,PDGFD,FGF1,GRIN2B,BRAF,KIT,PFN2,LPAR4,INS1,MLLT4 |
| Epstein-Barr virus infection | POLR2E,YWHAG,SNW1,TBPL1,GTF2E1,HLA-DPA1,CSNK2A2,POLR2J2,YWHAB,PIK3R3 |
| Amyotrophic lateral sclerosis (ALS) | ALS2,BID,NEFH,PPP3R1,CCS,GPX1,NEFM,BCL2,TOMM40,APAF1 |
| Influenza A | HLA-DMB,IFIH1,MAPK12,OAS1,IFNA14,IFNA2,IL12A,PABPN1L,FAS,PIK3CG |
| MAPK signaling pathway | HRAS,NLK1,NGF,ELK4,CACNA2D1,RRAS2,TAOK3,CACNG6,EGFRA,PLA2G4F |
| GnRH signaling pathway | MAPK8,MAPK12,PRKACG,PLD1A,GNRH2,MMP14A,CALM,CALM3,MAP3K3,CALM4 |
| Fc epsilon RI signaling pathway | AKT1,VAV3,MAPK1,FCER1A,HRAS,RAC3,RAC1,MAP2K6,PIK3CA,PIK3CG |
| Toll-like receptor signaling pathway | TLR4BB,IKBKG,PIK3CD,STAT1B,IFNA2,NFKBIA,IFNA14,STAT1,MAPK13,IL-8 |
| TNF signaling pathway | PTGS2,BIRC3,TNFRSF1A,MAGI2,MAP3K7,CXCL2,MAPK8,AKT2,PIK3R5,TRAF3 |
Protein Function
MAP2K3 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | ADRA2A,BAG5,TRIM5,ZC3HC1,TBC1D14,BCL10,FBXO7,ITGB2,PTPRR,MSN |
| ATP binding | UBE2S,UBE2G1B,ACSM2,STK19,EPHA7,FANCM,ATP1A1A.4,MCMDC2,ABCB1A,DGUOK |
| protein binding | CLEC7A,GRN,PSMD6,CHORDC1,ANXA5,GIMAP5,LXN,DVL2,KIAA0146,RGS1 |
| protein serine/threonine kinase activity | ATM,LRRK2,ACVR1BA,STK10,SMOK3B,RPS6KA3,TRIO,PAK2B,SMG1,PRKDC |
| protein tyrosine kinase activity | EGFR,FGFR1,CLK3,SHC1,BAZ1B,TESK2,FGFR2,KITB,DYRK1B,KIAA1804 |
| MAP kinase kinase activity | MAP2K6,MAPK10,MAPK14,MAPKAPK5,MAP2K2B,PAK3,LRRK2,MAP2K2,MAP3K14,MAP2K7 |
Interacting Protein
MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.
LRRK2;MAPK14;DYRK1B;TINF2;MAP3K5;MAP2K6;PKN1;MAPK14;TAOK2;MAP3K4;ALDOC;RPL13
Resources
Research Area
Apoptosis Intracellular KinasesIntracellular Kinases in the Akt Pathway
Mitogen-Activated Protein Kinase Kinases (MEKs/MKKs)
NOD-like Receptors and the Inflammasome
IL-1 Family Signaling Molecules
Related Services
Related Products
References
- Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
- Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
