Recombinant Human LYNA, GST-tagged, Active

• Cat.No.: LYNA-344H
• Product Overview: Recombinant full-length human LYN A was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=81 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: LYN A is a member of the Src-family of protein kinases that participate in signaling pathways of a variety of cell surface receptors and are localized to the cytoplasmic side of the plasma membrane. LYN A is biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway. The trafficking of LYN A from the Golgi apparatus to the plasma membrane is inhibited by deletion of the kinase domain but not by kinase inactivation. The kinase domain of LYN A plays a role in LYN A trafficking besides catalysis of substrate phosphorylation. cDNA microarray analysis revealed that LYN A may be involved in the changes that are related to tumor pathogenesis.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ]
• Synonyms: LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; EC 2.7.10.2
• Gene ID: 4067
• mRNA Refseq: NM_001111097
• Protein Refseq: NP_001104567
• MIM: 165120
• UniProt ID: P07948
• Chromosome Location: 8q13
• Pathway: B cell receptor signaling pathway; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Hemostasis; Signaling in Immune system; Fc epsilon RI signaling pathway
• Function: ATP binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; receptor signaling protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding