Recombinant Human LYNA, GST-tagged

• Cat.No.: LYNA-759H
• Product Overview: Recombinant Human LYNA protein (Met 1 - Pro 512), fused with the GST tag at the N-terminus, was expressed inBaculovirus.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-512 a.a.
• Description: V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, also known as LYN, is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells and in neural tissues. In various hematopoietic cells, LYN has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR), CD40, or CD19. Following engagement of the B cell receptors, LYN undergoes rapid phosphorylation and activation.
• Molecular Mass: The recombinant human LYN / GST chimera consists of 736 amino acids and predicts a molecular mass of 84.8 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Met.
• Purity: > 94% as determined by SDS-PAGE.
• Formulation: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0 , 0.5mM Reduced Glutathione, 10%gly, 0.5mM PMSF.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Storage And Stability: Store it under sterile conditions at -70⁰C. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens ]
• Synonyms: LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog; EC 2.7.10.2
• Gene ID: 4067
• mRNA Refseq: NM_001111097
• Protein Refseq: NP_001104567
• MIM: 165120
• UniProt ID: P07948
• Chromosome Location: 8q13
• Pathway: B cell receptor signaling pathway; Chemokine signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Hemostasis; Signaling in Immune system; Fc epsilon RI signaling pathway
• Function: ATP binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; receptor signaling protein tyrosine kinase activity; transferase activity; ubiquitin protein ligase binding