Recombinant Human LRPAP1 Protein, MYC/DDK-tagged

• Cat.No.: LRPAP1-848H
• Product Overview: Recombinant human LRPAP1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 37.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: LDL receptor related protein associated protein 1[ Homo sapiens ]
• Official Symbol: LRPAP1
• Synonyms: A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP; MYP23; RAP
• Gene ID: 4043
• mRNA Refseq: NM_002337.3
• Protein Refseq: NP_002328
• MIM: 104225

Reviews

12/17/2021

This technical support is invaluable, especially for researchers who may be new to working with LRPAP1 protein or if they encounter specific difficulties while conducting their experiments.

12/20/2020

They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

06/20/2016

the manufacturer's technical expertise can be advantageous to researchers.

Q&As

Can LRPAP1 be a target for therapeutic interventions, and if so, in what diseases?

LRPAP1 may be a potential therapeutic target in diseases where its interactions with LRP1 play a crucial role, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.

In what ways does LRPAP1 influence the immune system, and how might this be relevant in clinical applications?

LRPAP1 has been implicated in immune system regulation, and its interactions with LRP1 may impact immune responses, suggesting potential applications in immunotherapy.

Are there any known genetic variations or mutations in the LRPAP1 gene associated with diseases?

Genetic variations or mutations in the LRPAP1 gene have been investigated in the context of certain diseases, and understanding these variations may provide insights into disease susceptibility and progression.

How does LRPAP1 contribute to the regulation of lipoprotein metabolism and cardiovascular health?

LRPAP1 plays a role in lipoprotein metabolism by influencing the function of LRP1, a receptor involved in the clearance of lipoproteins from the circulation, thus impacting cardiovascular health.

How might the study of LRPAP1 contribute to personalized medicine approaches in the future?

Understanding the role of LRPAP1 in various diseases may contribute to personalized medicine by identifying individuals who could benefit from targeted therapies based on their specific genetic or molecular profiles.