Recombinant Human LRP6 Protein, MYC/DDK-tagged

• Cat.No.: LRP6-01H
• Product Overview: Purified recombinant protein of Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6) with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
• Molecular Mass: 178.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method.
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]
• Official Symbol: LRP6
• Synonyms: LRP6; LDL receptor related protein 6; ADCAD2; STHAG7; low-density lipoprotein receptor-related protein 6; LRP-6
• Gene ID: 4040
• mRNA Refseq: NM_002336
• Protein Refseq: NP_002327
• MIM: 603507
• UniProt ID: O75581