Recombinant Human LAT2, His-tagged

• Cat.No.: LAT2-2487H
• Product Overview: Recombinant human NTAL, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW = 26.2 kDa (238aa).

Specification

• Cat. No.: LAT2-2487H
• Description: NTAL (non-T cell activation linker), as known as LAT2, is transmembrane adaptor protein (TRAP) associated with glycolipid-enriched membrane fractions (GEM or lipid rafts). This protein is primarily expressed in spleen and hematopoietic cells, such as B cells, mast cells, NK cells, and monocytes, but not resting T cells. Defects in NTAL may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS).
• Source: E.coli.
• Form: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol.
• Purity: > 80% by SDS – PAGE.
• Concentration: 0.25 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: LAT2 linker for activation of T cells family, member 2 [ Homo sapiens ]
• Synonyms: linker for activation of T cells family, member 2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15; LAT2; linker for activation of T-cells family member 2; OTTHUMP00000213098; non-T cell activation linker; non-T-cell activation linker; linker for activation of B cells; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosome region 5; Williams-Beuren syndrome chromosome region 15; williams-Beuren syndrome chromosomal region 5 protein; williams-Beuren syndrome chromosomal region 15 protein; OTTHUMP00000179119; Williams-Beuren syndrome chromosomal region 15 protein; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; WBS15
• Gene ID: 7462
• mRNA Refseq: NM_014146
• Protein Refseq: NP_054865
• MIM: 605719
• UniProt ID: Q9GZY6
• Chromosome Location: 7q11.23
• Function: SH2 domain binding; protein binding