LAT2
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Official Full Name
linker for activation of T cells family, member 2 -
Overview
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental;disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all;encoding the same protein. -
Synonyms
LAT2;linker for activation of T cells family, member 2;WBSCR5, WBSCR15, Williams Beuren syndrome chromosome region 5;linker for activation of T-cells family member 2;HSPC046;LAB;linker for activation of B cells;linker for activation of T cells;transmembrane adaptor 2;non T cell activation linker;NTAL;WSCR5;non-T-cell activation linker;linker for activation of B-cells;membrane-associated adapter molecule;Williams-Beuren syndrome chromosomal region 5 protein;Williams-Beuren syndrome chromosomal region 15 protein;linker for activation of T cells, transmembrane adaptor 2;WBSCR5;WBSCR15
Recombinant Proteins
- Chicken
- Rhesus macaque
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
LAT2 involved in several pathways and played different roles in them. We selected most pathways LAT2 participated on our site, such as B Cell Receptor Signaling Pathway,Fc epsilon receptor (FCERI) signaling,Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Innate Immune System | CFHL3,DUSP3,CLEC5A,S100A12,FCN3,CLEC6A,MAP3K8,CNPY3,CFHL1,DEFB4A |
| Fc epsilon receptor (FCERI) signaling | TAB1,ITK,GRAP2A,GRAP2B,LCP2A,RASGRP2 |
| Fc-epsilon receptor I signaling in mast cells | ITK,PTPN13,DOK1,S1PR1 |
| B Cell Receptor Signaling Pathway | NFATC1,MAP4K1,GSK3B,NFKB1,PIK3CA,RAC1,cgr2b,DUSP6,AKT1,PLCG2 |
| Immune System | KIFAP3,TLR6,DEFB1,GBP4,TXNIPA,KIF11,GHRB,UBE2E3,PVRL2L,ASB3 |
Protein Function
LAT2 has several biochemical functions, for example, SH2 domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAT2 itself. We selected most functions LAT2 had, and list some proteins which have the same functions with LAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH2 domain binding | NUP62,DAG1,JAK2,PTK2,SYP,SYNGR3,LILRB1,SIT1,SHCBP1,SRC |
| protein binding | NPLOC4,SPOP,F12,DNAJA3,ASNA1,TIMP2,MAP3K5,CTNNBIP1,FAM9C,HDAC3 |
Interacting Protein
LAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAT2.
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References
- Imai, Y; Apakupakul, K; et al. Investigation of the Mechanism by Which Herpes Simplex Virus Type 1 LAT Sequences Modulate Preferential Establishment of Latent Infection in Mouse Trigeminal Ganglia. JOURNAL OF VIROLOGY 83:7873-7882(2009).
- Amaral, JS; Pinho, MJ; et al. Regulation of amino acid transporters in the rat remnant kidney. NEPHROLOGY DIALYSIS TRANSPLANTATION 24:2058-2067(2009).
