Recombinant Human Kruppel-like factor 7 (ubiquitous), His-tagged

• Cat.No.: KLF7-220H
• Product Overview: KLF7, 1-302aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-302 a.a.
• Description: KLF7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. Recombinant human KLF7 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 35.8kDa (325aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDVLASY SIFQELQLVH DTGYFSALPS LEETWQQTCL ELERYLQTEP RRISETFGED LDCFLHASPP PCIEESFRRL DPLLLPVEAA ICEKSSAVDI LLSRDKLLSE TCLSLQPASS SLDSYTAVNQ AQLNAVTSLT PPSSPELSRH LVKTSQTLSA VDGTVTLKLV AKKAALSSVK VGGVATAAAA VTAAGAVKSG QSDSDQGGLG AEACPENKKR VHRCQFNGCR KVYTKSSHLK AHQRTHTGEK PYKCSWEGCE WRFARSDELT RHYRKHTGAK PFKCNHCDRC FSRSDHLALH MKRHI
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: KLF7 Kruppel-like factor 7 (ubiquitous) [ Homo sapiens ]
• Official Symbol: KLF7
• Synonyms: KLF7; Kruppel-like factor 7 (ubiquitous); Krueppel-like factor 7; UKLF; ubiquitous krueppel-like factor; ubiquitous Kruppel-like transcription factor
• Gene ID: 8609
• mRNA Refseq: NM_003709
• Protein Refseq: NP_003700
• MIM: 604865
• UniProt ID: O75840
• Chromosome Location: 2q32
• Pathway: Adipogenesis, organism-specific biosystem
• Function: DNA binding; metal ion binding; nucleic acid binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; zinc ion binding