Recombinant Human KLK6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: KLK6-2781H
• Product Overview: KLK6 MS Standard C13 and N15-labeled recombinant protein (NP_001012982) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Molecular Mass: 26.9 kDa
• AA Sequence: MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAKTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: KLK6 kallikrein-related peptidase 6 [ Homo sapiens (human) ]
• Official Symbol: KLK6
• Synonyms: KLK6; kallikrein-related peptidase 6; kallikrein 6 (neurosin, zyme), protease, serine, 18, PRSS9, PRSS18; kallikrein-6; Bssp; Klk7; neurosin; zyme; protease M; serine protease 9; serine protease 18; hK6; SP59; PRSS9; PRSS18; MGC9355
• Gene ID: 5653
• mRNA Refseq: NM_001012964
• Protein Refseq: NP_001012982
• MIM: 602652
• UniProt ID: Q92876