Recombinant Human KLK6 protein, His & GST-tagged

• Cat.No.: KLK6-800H
• Product Overview: Recombinant Human KLK6 aa. (Glu17~Lys244 (Accession # Q92876)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: Glu17~Lys244
• Description: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 57.1kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 6.3.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: KLK6 kallikrein related peptidase 6 [ Homo sapiens (human) ]
• Official Symbol: KLK6
• Synonyms: hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; kallikrein 6; neurosin; protease M; serine protease 18; serine protease 9; zyme; kallikrein-6
• Gene ID: 5653
• mRNA Refseq: NM_001012964.2
• Protein Refseq: NP_001012982.1
• UniProt ID: Q92876