Recombinant Human Killer Cell Immunoglobulin-like Receptor, Three Domains, Long Cytoplasmic Tail, 1, His-tagged
Cat.No. : | KIR3DL1-349H |
Product Overview : | Recombinant His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (132 aa, 15 kDa). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Description : | The three Ig-domain from of inhibitory killer cell Ig-like receptor 1(KIR3DL1,NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DLl recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs(ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. |
Formulation : | Liquid. In 25 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl. |
Molecular Weight : | 15 kDa (132 aa). |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequence : | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Synonyms | |
Gene Name | KIR3DL1 |
Gene ID | 3811 |
mRNA Refseq | NM_013289.2 |
Protein Refseq | NP_037421.2 |
MIM | 604946 |
UniProt ID | P43629 |
Chromosome Location | 19q13.4 |
Pathway | Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Signaling in Immune system. |
Function | HLA-B specific inhibitory MHC class I receptor activity; receptor activity. |
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Not For Human Consumption!
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