Recombinant Human KDM5C, GST-tagged

• Cat.No.: KDM5C-7032H
• Product Overview: Recombinant human KDM5C (1-671) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-671 aa
• Description: KDM5C or lysine (K)-specific demethylase 5C is a member of the SMCY homolog family that encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers.KDM5C is mainly expressed in brain and skeletal muscle. KDM5C is involved in the regulation of transcription and chromatin remodelling that cause X-linked mental retardation. KDM5C is also essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~118 kDa
• Purity: >80%
• Applications: Western Blot
• Storage: Store at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: KDM5C lysine (K)-specific demethylase 5C [ Homo sapiens ]
• Official Symbol: KDM5C
• Synonyms: KDM5C; lysine (K)-specific demethylase 5C; JARID1C, jumonji, AT rich interactive domain 1C , Jumonji, AT rich interactive domain 1C (RBP2 like) , SMCX, Smcy homolog, X linked (mouse); lysine-specific demethylase 5C; DXS1272E; XE169; protein SmcX; selected cDNA on X; Smcy homolog, X-linked; Smcx homolog, X chromosome; histone demethylase JARID1C; JmjC domain-containing protein SMCX; Jumonji/ARID domain-containing protein 1C; Jumonji, AT rich interactive domain 1C (RBP2-like); MRXJ; SMCX; MRXSJ; MRXSCJ; JARID1C
• Gene ID: 8242
• mRNA Refseq: NM_001146702
• Protein Refseq: NP_001140174
• MIM: 314690
• UniProt ID: P41229
• Chromosome Location: Xp11.22-p11.21
• Function: DNA binding; histone demethylase activity (H3-K4 specific); metal ion binding; molecular_function; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding