KDM5C

  • Official Full Name

    lysine (K)-specific demethylase 5C

  • Overview

    This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

  • Synonyms

    KDM5C;lysine (K)-specific demethylase 5C;MRXJ;SMCX;MRX13;MRXSJ;XE169;MRXSCJ;JARID1C;DXS1272E;lysine-specific demethylase 5C;protein SmcX;selected cDNA on X;Smcy homolog, X-linked;Smcx homolog, X chromosome;histone demethylase JARID1C;mental retardation, X-linked 13;JmjC domain-containing protein SMCX;Jumonji/ARID domain-containing protein 1C;Jumonji, AT rich interactive domain 1C (RBP2-like)

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Flag
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KDM5C-45H Active Recombinant Human KDM5C, FLAG-tagged Sf9 Cells Human Flag
KDM5C-1604H Recombinant Human Lysine (K)-Specific Demethylase 5C, GST-tagged Sf9 Cells Human GST 1-671 a.a.
KDM5C-2383R Recombinant Rhesus monkey KDM5C Protein, His-tagged Mammalian Cells Rhesus macaque His
KDM5C-6642Z Recombinant Zebrafish KDM5C Mammalian Cells Zebrafish His
KDM5C-7032H Recombinant Human KDM5C, GST-tagged Sf9 Cells Human GST 1-671 aa
KDM5C-8596M Recombinant Mouse KDM5C Protein Mammalian Cells Mouse His
KDM5C-2204R Recombinant Rhesus Macaque KDM5C Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
KDM5C-2204R-B Recombinant Rhesus Macaque KDM5C Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
KDM5C-4784M Recombinant Mouse KDM5C Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KDM5C-4784M-B Recombinant Mouse KDM5C Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KDM5C involved in several pathways and played different roles in them. We selected most pathways KDM5C participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin organization WDR77,PHF8,ACTL6B,ING4,TADA1,SMARCD3,BRD1,PHF17,DNMT3A,JADE1
    HDMs demethylate histones KDM1A,KDM5D,KDM4B,PHF2,KDM5BA,KDM3B,KDM5A,KDM2AA,JMJD6,KDM6B
    Chromatin modifying enzymes ATF7IP,ELP3,MCRS1,EHMT2,ACTL6B,MBD3B,EPC1,KDM2AA,C17orf81,KDM4A

    Protein Function

    KDM5C has several biochemical functions, for example, DNA binding,histone demethylase activity (H3-K4 specific),oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5C itself. We selected most functions KDM5C had, and list some proteins which have the same functions with KDM5C. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding RNF144A,SLC30A7,AEBP1,CPB1,MAN2A1,LTA4H,KMT2A,RBM14B,ZFR,RNF141
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors HIF1AN,C14orf169,P4HTM,EGLN3,EGLN1,EGLN2,JHDM1D,KDM5A,ALKBH8,ALKBH4
    DNA binding PML,NR6A1,POLD1,TOMM20A,HNF1BA,HOXB6B,EBF4,NUPR1,HER9,H2AFB1
    histone demethylase activity (H3-K4 specific) KDM5B,C14orf169,KDM1A,KDM5D

    Interacting Protein

    KDM5C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5C.

    h31_bovin;zipA;ptsN1;CSNK2A1;XPO1;E2F6;TOX4;VPS41;MAX;CSNK2B;SET;MGA;ZNF687;ZNF592;CENPK;TSPYL2;SLC25A22;ZNF532;MBD2;ZMYND8

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