Recombinant Human KCNIP3, His-tagged

• Cat.No.: KCNIP3-2873H
• Product Overview: Recombinant humanKCNIP3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: KCNIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins containing EF-hand-like domains. This protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer"s disease.
• Sequence: MGSSHHHHHH SSGLVPRGSH MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI.
• Purity: > 90% by SDS – PAGE.
• MW: 31.4 kDa (276aa) confirmed by MALDI-TOF.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 50mM NaCl, 0.1mM PMSF.
• Concentration: 1mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KCNIP3 Kv channel interacting protein 3, calsenilin [ Homo sapiens ]
• Synonyms: KCNIP3; Kv channel interacting protein 3, calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; kv channel-interacting protein 3; potassium channel interacting protein 3; CSEN, DREAM, KCHIP3, MGC18289
• Gene ID: 30818
• mRNA Refseq: NM_001034914
• Protein Refseq: NP_001030086
• MIM: 604662
• UniProt ID: Q9Y2W7
• Chromosome Location: 2q21.1
• Pathway: Metabolic pathways; Nicotinate and nicotinamide metabolism; Metabolism of nucleotides
• Function: drug binding; nucleoside binding; purine-nucleoside phosphorylase activity; DNA binding; specific transcriptional repressor activity; voltage-gated ion channel activity; transcription corepressor activity