Recombinant Full Length Human KCNIP3 Protein, GST-tagged

• Cat.No.: KCNIP3-2153HF
• Product Overview: Human CSEN full-length ORF ( AAH12850, 1 a.a. - 256 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 53.90 kDa
• Protein length: 256 amino acids
• AA Sequence: MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: KCNIP3 Kv channel interacting protein 3, calsenilin [ Homo sapiens ]
• Official Symbol: KCNIP3
• Synonyms: KCNIP3; Kv channel interacting protein 3, calsenilin; calsenilin, presenilin binding protein, EF hand transcription factor , CSEN; calsenilin; DREAM; KCHIP3; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; MGC18289
• Gene ID: 30818
• mRNA Refseq: NM_001034914
• Protein Refseq: NP_001030086
• MIM: 604662
• UniProt ID: Q9Y2W7