Recombinant Human Kallikrein-related Peptidase 3, His-tagged

• Cat.No.: KLK3-6791H
• Product Overview: Recombinant humanKLK3 protein, fused to His-tag at N-terminus, was expressed in E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Prostate-specificantigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is amember of the kallikrein-related peptidase family. Kallikreins are a subgroupof serine proteases having diverse physiological functions. Growing evidencesuggests that many kallikreins are implicated in carcinogenesis and some havepotential as novel cancer and other disease biomarkers. This protein is oneof the fifteen kallikrein subfamily members located in a cluster onchromosome 19 and is a protease present in seminal plasma. It is thought tofunction normally in the liquefaction of seminal coagulum, presumably byhydrolysis of the high molecular mass seminal vesicle protein. Serum level ofthis protein, called PSA in the clinical setting, is useful in the diagnosisand monitoring of prostatic carcinoma
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 0.4M Urea
• Molecular Weight: 28.8 kDa (262aa)
• Purity: > 90% by SDS -PAGE
• Concentration: 1mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMIVGGW ECEKHSQPWQ VLVASRGRAV CGGVLVHPQW VLTAAHCIRN KSVILLGRHSLFHPEDTGQV FQVSHSFPHP LYDMSLLKNR FLRPGDDSSH DLMLLRLSEP AELTDAVKVM DLPTQEPALGTTCYASGWGS IEPEEFLTPK KLQCVDLHVI SNDVCAQVHP QKVTKFMLCA GRWTGGKSTC SGDSGGPLVCNGVLQGITSW GSEPCALPER PSLYTKVVHY RKWIKDTIVA NP
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: KLK3kallikrein-related peptidase 3 [ Homo sapiens ]
• Official Symbol: KLK3
• Synonyms: KLK3; kallikrein-related peptidase3; APS, kallikrein 3, (prostate specific antigen); prostate-specific antigen;PSA
• Gene ID: 354
• mRNA Refseq: NM_001648
• Protein Refseq: NP_001639
• MIM: 176820
• Uniprot ID: P07288
• Chromosome Location: 19q13.41
• Pathway: Coregulation of Androgen receptoractivity, organism-specific biosystem; Diabetes pathways, organism-specificbiosystem; FOXA1 transcription factor network, organism-specific biosystem;Pathways in cancer, organism-specific biosystem; Prostate cancer,organism-specific biosystem
• Function: peptidase activity; proteinbinding; serine-type endopeptidase activity; serine-type peptidase activity