KLK3
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Official Full Name
kallikrein-related peptidase 3 -
Overview
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
KLK3;kallikrein-related peptidase 3;APS;PSA;hK3;KLK2A1;prostate-specific antigen;seminin;P-30 antigen;kallikrein-3;semenogelase;gamma-seminoprotein;prostate specific antigen
Recombinant Proteins
- Human
- Rhesus macaque
- HEK293
- Human seminal fluid
- Mammalian Cell
- E.coli
- Human Cell
- HEK293 cells
- E. coli
- HEK293F
- Mammalian cells
- HEK293T
- Human Seminal Fluid
- Human Semen
- Wheat Germ
- In Vitro Cell Free System
- Human Seminal fluid
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
KLK3 involved in several pathways and played different roles in them. We selected most pathways KLK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
KLK3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KLK3 itself. We selected most functions KLK3 had, and list some proteins which have the same functions with KLK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
KLK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK3.
Resources
Research Area
Fibrinolysis SystemPlasmin/Plasminogen and Kallikrein/Kinin Systems
Cancer Biomarkers in Clinical Practice
Prostate Cancer Biomarkers
Tumor Antigens
Related Services
Related Products
References
- Korbakis, D; Prassas, I; et al. Delineating monoclonal antibody specificity by mass spectrometry. JOURNAL OF PROTEOMICS 114:115-124(2015).
- Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).
