Recombinant Human K(Lysine) Acetyltransferase 6B, GST-tagged

• Cat.No.: KAT6B-1600H
• Product Overview: Recombinant human KAT6B (MYST4) (657-1069; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: KAT6B-1600H
• Description: KAT6B is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which is ubiquitously expressed in adult human tissues. KAT6B is a 1781aa-residue protein that contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus. These domains of KAT6B may be involved in both positive and negative regulation of transcription and also involved in cerebral cortex development. KAT6B is important for cellular aging, proliferation, positive and negative transcriptional regulation and DNA damage repair.
• Applications: Western Blot
• Molecular Weight: 76 kDa
• Expression System: Sf9 insect cells using baculovirus.
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: > 95 %
• Concentration: 0.1 ug/ul
• Sequences: 657-1069; contains the catalytic domain.
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Protein length: 657-1069 a.a.

Gene Information

• Gene Name: KAT6B K(lysine) acetyltransferase 6B [ Homo sapiens ]
• Official Symbol: KAT6B
• Synonyms: KAT6B; MYST4; DKFZp313G1618; FLJ90335; MORF; MOZ2; qkf; querkopf qkf; MORF; KIAA0383; querkopf; MYST histone acetyltransferase (monocytic leukemia) 4; Histone acetyltransferase MORF; Histone acetyltransferase MOZ2; Monocytic leukemia zinc finger protein-related factorKI; MYST-4; EC2.3.1.48; histone acetyltransferase MYST4; OTTHUMP00000019869
• Gene ID: 23522
• mRNA Refseq: NM_012330
• Protein Refseq: NP_036462
• MIM: 605880
• UniProt ID: Q8WYB5
• Chromosome Location: 10q22.2
• Function: DNA binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; protein binding; transcription factor binding; zinc ion binding