Recombinant Human Interferon, Beta 1, Fibroblast

• Cat.No.: IFNB1-19H
• Product Overview: Recombinant Human Interferon-beta 1a produced inCHO (Chinese Hamster Ovarian) cellsis a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton. IFN-beta1a is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: IFNB1-19H
• Description: Interferon-beta 1b has antiviral, antibacterial and anticancer activities.
• Source: CHO (Chinese Hamster Ovarian) cells
• Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Tyr-Asn-Leu-Leu.
• Physical Appearance: Lyophilized from 1mg/ml solution containing 91 mg Human Albumin, and 620mg mannitol, and 9 mg Sodium Acetate.
• Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Lyophilized from a concentrated 1mg/ml solution containing PBS 7.4.
• Solubility: It is recommended to reconstitute the lyophilized Interferon beta 1a in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 270 x 10⁶ IU/mg.
• Storage: Lyophilized Interferon-beta 1a although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution IFN-Beta1a should be stored at 4℃ between 2-7 days and for future use below -18℃.Please prevent freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ]
• Synonyms: IFNB1; Interferon, beta 1, fibroblast; IFB; IFF; IFNB; MGC96956; Interferon beta; Leukocyte interferon; B cell interferon; Type I interferon; IFNB1; IFN-b 1a; IFN-beta; OTTHUMP00000021131; Fibroblast interferon
• Gene ID: 3456
• mRNA Refseq: NM_002176
• Protein Refseq: NP_002167
• MIM: 147640
• UniProt ID: P01574
• Chromosome Location: 9p21
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway
• Function: cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity

Reviews

06/24/2021

The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

08/29/2020

the IFNB1 protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

11/08/2018

manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

Q&As

Are there any contraindications for IFNB1 treatment?

IFNB1 is generally not recommended for individuals with a history of hypersensitivity to interferons or other components of the drug. It should be used with caution in patients with certain pre-existing medical conditions.

Can IFNB1 be used in cancer treatment?

IFNB1 is being investigated for its potential role in cancer treatment due to its immunomodulatory effects. Clinical trials are ongoing to evaluate its efficacy in various types of cancer.

What are the potential side effects of IFNB1 treatment?

Common side effects include flu-like symptoms, injection site reactions, and changes in blood cell counts. Serious side effects are rare but can include liver problems and allergic reactions.

How is IFNB1 administered in clinical settings?

IFNB1 is often administered through subcutaneous or intramuscular injections. The frequency and dosage depend on the specific condition being treated.

In what other conditions is IFNB1 protein clinically utilized?

IFNB1 is also used in the treatment of certain viral infections, such as hepatitis B and C. It has antiviral properties that can inhibit viral replication.