Recombinant Human Interferon, Beta 1, Fibroblast
Cat.No. : | IFNB1-19H |
Product Overview : | Recombinant Human Interferon-beta 1a produced inCHO (Chinese Hamster Ovarian) cellsis a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton. IFN-beta1a is purified by proprietary chromatographic techniques. |
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Species : | Human |
Source : | CHO |
Tag : | Non |
Description : | Interferon-beta 1b has antiviral, antibacterial and anticancer activities. |
Amino Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Tyr-Asn-Leu-Leu. |
Physical Appearance : | Lyophilized from 1mg/ml solution containing 91 mg Human Albumin, and 620mg mannitol, and 9 mg Sodium Acetate. |
Purity : | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | Lyophilized from a concentrated 1mg/ml solution containing PBS 7.4. |
Solubility : | It is recommended to reconstitute the lyophilized Interferon beta 1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Biological Activity : | The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 270 x 10⁶ IU/mg. |
Storage : | Lyophilized Interferon-beta 1a although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution IFN-Beta1a should be stored at 4℃ between 2-7 days and for future use below -18℃.Please prevent freeze-thaw cycles. |
Gene Name | IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ] |
Synonyms | IFNB1; Interferon, beta 1, fibroblast; IFB; IFF; IFNB; MGC96956; Interferon beta; Leukocyte interferon; B cell interferon; Type I interferon; IFNB1; IFN-b 1a; IFN-beta; OTTHUMP00000021131; Fibroblast interferon |
Gene ID | 3456 |
mRNA Refseq | NM_002176 |
Protein Refseq | NP_002167 |
MIM | 147640 |
UniProt ID | P01574 |
Chromosome Location | 9p21 |
Pathway | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway |
Function | cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity |
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Not For Human Consumption!
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