Recombinant Human Intercellular Adhesion Molecule 3

• Cat.No.: ICAM3-1627H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50) is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins that bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signaling molecule. ICAM-3 is potentially the most important ligand for LFA-1 in the initiation of the immune response because the expression of ICAM-1 on resting leukocytes is low.1 ICAM-3 is closely related to ICAM-1.ICAM-3 is essentially restricted to the haemopoietic system and is reciprocal in its expression to ICAM-1, in that it is present on resting cells and its level falls as a result of cell activation.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human ICAM-3 is Mr 76.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: ICAM3 intercellular adhesion molecule 3 [ Homo sapiens ]
• Synonyms: ICAM3; intercellular adhesion molecule 3; CD50; CDW50; ICAM-R; CDw50; intercellular adhesion molecule-3; Intercellular adhesion molecule 3; ICAM-3; CD50 antigen
• Gene ID: 3385
• mRNA Refseq: NM_002162
• Protein Refseq: NP_002153
• MIM: 146631
• UniProt ID: P32942
• Chromosome Location: 19p13.3-p13.2
• Pathway: Cell adhesion molecules (CAMs); Integrin cell surface interactions; Signaling in Immune system
• Function: integrin binding