Recombinant Human Intercellular Adhesion Molecule 3

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Cat. No. :	ICAM3-1627H
Description :	Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50) is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins that bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signaling molecule. ICAM-3 is potentially the most important ligand for LFA-1 in the initiation of the immune response because the expression of ICAM-1 on resting leukocytes is low.1 ICAM-3 is closely related to ICAM-1.ICAM-3 is essentially restricted to the haemopoietic system and is reciprocal in its expression to ICAM-1, in that it is present on resting cells and its level falls as a result of cell activation.
Source :	Mammalian cells
State Of Matter :	Lyophilized.
Purity :	>95% by SDS Page and analyzed by silver stain.
Endotoxin :	<1.0 EU/µg as determined by the LAL method.
Molecular Weight :	The predicted molecular weight of Recombinant Human ICAM-3 is Mr 76.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
Storage And Stability :	This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Tag :	Non

Gene Name	ICAM3 intercellular adhesion molecule 3 [ Homo sapiens ]
Synonyms	ICAM3; intercellular adhesion molecule 3; CD50; CDW50; ICAM-R; CDw50; intercellular adhesion molecule-3; Intercellular adhesion molecule 3; ICAM-3; CD50 antigen
Gene ID	3385
mRNA Refseq	NM_002162
Protein Refseq	NP_002153
MIM	146631
UniProt ID	P32942
Chromosome Location	19p13.3-p13.2
Pathway	Cell adhesion molecules (CAMs); Integrin cell surface interactions; Signaling in Immune system
Function	integrin binding