Recombinant Human Insulin Receptor, GST-tagged, Active

• Cat.No.: INSR-331H
• Product Overview: Recombinant human InsR (1011-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 70 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1011-end a.a.
• Description: InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis.
• Sequence: 1011-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: INSR insulin receptor [ Homo sapiens ]
• Synonyms: INSR; insulin receptor; HHF5; CD220; EC 2.7.10.1; IR; CD220 antigen; Insulin receptor subunit alpha; Insulin receptor subunit beta
• Gene ID: 3643
• mRNA Refseq: NM_000208
• Protein Refseq: NP_000199
• MIM: 147670
• UniProt ID: P06213
• Chromosome Location: 19p13.3-p13.2
• Pathway: Adherens junction; Insulin signaling pathway; Type II diabetes mellitus
• Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin receptor activity; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; manganese ion binding; metal ion binding; nucleotide binding; phosphoinositide 3-kinase binding; protein complex binding; protein phosphatase binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity