Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged

• Cat.No.: IKBKG-1028H
• Product Overview: Recombinant full-length human IKBKG was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: IKBKG is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKBKG forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha. IKBKG associates with activated ATM after the induction of DNA double-strand breaks. ATM phosphorylates serine-85 of IKBKG to promote its ubiquitin-dependent nuclear export.
• Applications: Western Blot
• Molecular Weight: 73 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0,25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Purity: > 95 %
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Activated TLR4 signalling; Acute myeloid leukemia; Adaptive Immunity Signaling; Adipocytokine signaling pathway; Apoptosis; Epithelial cell signaling in Helicobacter pylori infection; FAS (CD95) signaling pathway; HTLV-I infection; IRAK1 recruits IKK comlex; MAPK signaling pathway; NLR proteins; Pancreatic cancer; p75(NTR)-mediated signaling

Gene Information

• Gene Name: IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [ Homo sapiens ]
• Official Symbol: IKBKG
• Synonyms: IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; IKK-gamma; NF-kappa-B essential modulator; IKKG; IKKAP1; OTTHUMP00000026026; OTTHUMP00000026027; OTTHUMP00000026028; OTTHUMP00000026029; OTTHUMP00000026030; OTTHUMP00000196183; OTTHUMP00000196183; OTTHUMP00000196186; OTTHUMP00000207079; OTTHUMP00000212188; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma
• Gene ID: 8517
• mRNA Refseq: NM_003639
• Protein Refseq: NP_003630
• MIM: 300248
• UniProt ID: Q9Y6K9
• Chromosome Location: Xq28
• Function: metal ion binding; protein binding; protein domain specific binding; signal transducer activity