IKBKG

  • Official Full Name

    IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

  • Overview

    NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-gamma) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IkappaB kinase that activates NF-kappaB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    IKBKG;inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma;incontinentia pigmenti , IP1, IP2;NF-kappa-B essential modulator;FIP 3;FIP3;Fip3p;IKK gamma;NEMO;IKKG;IKKAP1;incontinentia pigmenti;IkB kinase gamma subunit;ikB kinase subunit gamma;NFkappaB essential modulator;NF-kappa-B essential modifier;I-kappa-B kinase subunit gamma;ikB kinase-associated protein 1;inhibitor of nuclear factor kappa-B kinase subunit gamma;IP;IP1;IP2;IPD2;FIP-3;AMCBX1;IKK-gamma

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • DDK
  • Myc
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
IKBKG-14134H Recombinant Human IKBKG, GST-tagged E.coli Human GST C-term-300a.a.
IKBKG-1028H Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-cells, Kinase Gamma, GST-tagged Sf9 Cells Human GST
IKBKG-195H Recombinant Human IKBKG, GST-tagged E.coli Human GST 2-418 a.a.
IKBKG-196H Recombinant Human IKBKG(D311N), GST-tagged E.coli Human GST 2-418 a.a.
IKBKG-2265Z Recombinant Zebrafish IKBKG Mammalian Cells Zebrafish His
IKBKG-3022R Recombinant Rat IKBKG Protein Mammalian Cells Rat His
IKBKG-489H Recombinant Human IKBKG Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
IKBKG-1054HFL Recombinant Full Length Human IKBKG Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IKBKG-1163H Recombinant Human IKBKG Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IKBKG-1163H-B Recombinant Human IKBKG Protein Pre-coupled Magnetic Beads HEK293 Human
Ikbkg-1233M Recombinant Mouse Ikbkg Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IKBKG-1238H Recombinant Human IKBKG protein, His-tagged E.coli Human His
IKBKG-2677R Recombinant Rat IKBKG Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IKBKG-2677R-B Recombinant Rat IKBKG Protein Pre-coupled Magnetic Beads HEK293 Rat
IKBKG-3089H Recombinant Human IKBKG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IKBKG-360H Recombinant Human IKBKG Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IKBKG-5509H Recombinant Human IKBKG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    IKBKG involved in several pathways and played different roles in them. We selected most pathways IKBKG participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway PRLR,PTK2,IKBKB,PPP2R1B,GNG3,RHEB,LAMB2,STK11,CCNE1,TNXB
    RIG-I-like receptor signaling pathway CASP8,DDX3,CASP10,IFNA13,IRF7,MAPK8,IL8L1,IL8L2,DHX58,TRIM25
    NOD-like receptor signaling pathway TRIP6,NLRP1,CXCL1,TAB2,MAPK3,IL8L2,CARD8,MAPK12,IL6,TAB3
    TNF signaling pathway MMP3,PIK3CG,FOS,NFKBIA,PIK3R2,RELA,FAS,MAP3K7IP3,MAPK9,IL15
    Chronic myeloid leukemia IKBKB,HDAC2,TGFB3,BCL2L1,RUNX1,MAPK3,CTBP2,STAT5A,CRKL,RELA
    Prostate Cancer ARID1A,IGF1R,ACTL6B,CREB5,BCL2,BAD,PTEN,NRAS,CREB3L3,CREB3L1
    Epstein-Barr virus infection HLA-DPA1,SPI1,HSPA1L,CCNA2,PSMC4,HSPB2,TRAF5,POLR2K,EIF2AK3,PRKACB
    Pancreatic cancer CASP9,MAPK8,RAD51,SMAD2,BRCA2,ARAF,PIK3CA,PIK3R2,TGFBR1,PIK3R3
    NF-kappa B signaling pathway MYD88,LY96,CCL4L2,RELA,ERC1,GADD45B,BLNK,CARD11,BCL2A1A,LTBR

    Protein Function

    IKBKG has several biochemical functions, for example, K63-linked polyubiquitin binding,linear polyubiquitin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKG itself. We selected most functions IKBKG had, and list some proteins which have the same functions with IKBKG. You can find most of the proteins on our site.

    Function Related Protein
    K63-linked polyubiquitin binding ZRANB1B,TNFAIP3,SQSTM1,SPRTN,RNF168,RNF169,ZRANB3,PRPF8,OTUD7B,UIMC1
    ubiquitin protein ligase binding TCP1,WASH1,UBE2C,MAP1LC3C,PRKAR2A,FZD5,PIAS4,VCL,MAP1LC3B,FZD6
    metal ion binding CENPT,SPNA1,CYB5A,PPP5C,ITGAV,ATP5S,PDE4C,ZFP287,ZNF354A,PRKD1
    peroxisome proliferator activated receptor binding PPARGC1A,ASXL1,NR0B2,ASXL2,CREBBP,EP300,HMGA1-RS1,HMGA1,MED1,PRMT2
    protein heterodimerization activity TYRO3,BAX,SMC3,IKZF3,PAFAH1B2,TCF3,MYH7,NOTCH1,VOX,NAE1
    protein domain specific binding HIST1H4N,HSPA5,HMGB2,SHC4,ICA1L,CRB3,ANGEL1,CNOT1,TUBB,SERPINB1A
    signal transducer activity CCR9A,VOPP1,ADORA2AA,LPAR2B,MTNR1AL,TAAR10A,CNOT7,PTGER1A,GNA12,OLFR493
    protein homodimerization activity PRPS2,PEX11B,TGFB2,NPM1,TFAP2A,GSTA4,FGFR1OP2,QPRT,HMOX1,UGT1A4
    protein binding SKIL,NTF3,ARF1,PPP2R5E,AKR1C1,CORO1B,BMI1,ALKBH3,CTNNA3,ORAI3

    Interacting Protein

    IKBKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKG here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKG.

    IKBKB

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