Recombinant Human IKBKG(D311N), GST-tagged

• Cat.No.: IKBKG-196H
• Product Overview: Recombinant human IKBKG(D311N) (amino acid residues 2-418), fused with N-terminal GST, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2-418 a.a.
• Description: NEMO functions as a high affinity receptor for linear ubiquitin chains and a low affinity receptor for long lysine-linked ubiquitin chains. It is thought that this phenomenon could explain quantitatively distinct NF-κB activation patterns in response to numerous cell stimuli (Kensche et al., 2012). NEMO is an integral component of the canonical IκB kinase (IKK) complex and is essential for the activation of IKKα and IKKβ, the protein kinase components of the complex.
• Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
• Molecular Mass: 74.9kDa
• Purity: >85% by SDS-PAGE
• Storage: 12 months at -70°C. Avoid multiple freeze/thaw cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [ Homo sapiens ]
• Official Symbol: IKBKG
• Synonyms: IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma
• Gene ID: 8517
• mRNA Refseq: NM_001099856
• Protein Refseq: NP_001093326
• MIM: 300248
• UniProt ID: Q9Y6K9
• Chromosome Location: Xq28
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem
• Function: metal ion binding; protein binding; protein domain specific binding; signal transducer activity