Recombinant Human IKBKG, GST-tagged

• Cat.No.: IKBKG-195H
• Product Overview: Recombinant human IKBKG (amino acid residues 2-418), fused with N-terminal GST, was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2-418 a.a.
• Description: NEMO (NFκB Essential Modifier) is the protypic member of a family of proteins that interact with Lys63-linked and linear polyubiquitin chains (Nanda et al.,2011). NEMO functions as a high affinity receptor for linear ubiquitin chains and a low affinity receptor for long lysine-linked ubiquitin chains. It is thought that this phenomenon could explain quantitatively distinct NF-κB activation patterns in response to numerous cell stimuli (Kensche et al., 2012).
• Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol
• Molecular Mass: 74.9kDa
• Purity: >85% by SDS-PAGE
• Storage: 12 months at -70°C. Avoid multiple freeze/thaw cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [ Homo sapiens ]
• Official Symbol: IKBKG
• Synonyms: IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; incontinentia pigmenti , IP1, IP2; NF-kappa-B essential modulator; FIP 3; FIP3; Fip3p; IKK gamma; NEMO; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; FIP-3; AMCBX1; IKK-gamma
• Gene ID: 8517
• mRNA Refseq: NM_001099856
• Protein Refseq: NP_001093326
• MIM: 300248
• UniProt ID: Q9Y6K9
• Chromosome Location: Xq28
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem
• Function: metal ion binding; protein binding; protein domain specific binding; signal transducer activity