Recombinant Human IDO1 Protein, His/Avi-tagged

• Cat.No.: IDO1-01H
• Product Overview: Human IDO1, also known as Indoleamine 2,3-dioxygenase 1, a.a. 2-403(end) with an N-terminal His-Avi-Tag, was expressed in an E. coli cell expression system.

Specification

• Species: Human
• Source: E.coli
• Tag: Avi&His
• Protein Length: 2-403 a.a.
• Description: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
• Form: Aqueous buffer solution
• Molecular Mass: 48 kDa
• Applications: Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
• Stability: At least 6 months at -80 centigrade
• Storage: At -80 centigrade
• Concentration: 1.12 mg/mL
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04 % Tween 20, 20 % glycerol

Gene Information

• Gene Name: IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens (human) ]
• Official Symbol: IDO1
• Synonyms: IDO1; indoleamine 2,3-dioxygenase 1; IDO; INDO; IDO-1; indoleamine 2,3-dioxygenase 1; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; EC 1.13.11.52
• Gene ID: 3620
• mRNA Refseq: NM_002164
• Protein Refseq: NP_002155
• MIM: 147435
• UniProt ID: P14902