Recombinant Human Human PIK3CB, His-tagged

• Cat.No.: PIK3CB-31095TH
• Product Overview: Recombinant full-length Human PIK3CB and PIK3R1 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins, MWt 111 and86kDa respectively.

Specification

• Description: Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al.
• Conjugation: HIS
• Biological activity: The Specific activity of PIK3CB-31095TH was determined to be 16.3 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide [ Homo sapiens ]
• Official Symbol: PIK3CB
• Synonyms: PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide; PIK3C1; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
• Gene ID: 5291
• mRNA Refseq: NM_006219
• Protein Refseq: NP_006210
• MIM: 602925
• Uniprot ID: P42338
• Chromosome Location: 3q21-qter
• Pathway: 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; binding; insulin receptor substrate binding; kinase activity