Recombinant Human HSPA (Heat Shock 70 KDa) Binding Protein, Cytoplasmic Cochaperone 1, His-tagged

• Cat.No.: HSPBP1-5041H
• Product Overview: Recombinant human HSPBP1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: HSPBP1-5041H
• Description: Hsp70-binding protein 1, also known as HSPBP1, belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for HSP 70, which exhibit varying degrees of compartment and species specificity. It is localized primarily in cytoplasm and nucleus but is also found extracellularly. HspBP1 binds to HSP 70, inhibits its activity and promotes dissociation of nucleotides from the HSP 70 ATPase domain. It is mainly expressed in heart and skeletal muscle.
• Concentration: 0.5 mg/ml
• Source: Human
• Host: E. coli
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 2mM DTT, 30% glycerol, 2mM EDTA and 0.1M NaCl.
• Purity: > 95% by SDS - PAGE
• Sequence: 1-362 amino acids: MGSSHHHHHH SSGLVPRGSH MSDEGSRGSR LPLALPPASQ GCSSGGGGGG GGGSSAGGSG NSRPPRNLQG LLQMAITAGS EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG AAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKL
• Molecular Mass: 41.6 kDa (382aa)
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 [ Homo sapiens ]
• Official Symbol: HSPBP1
• Synonyms: HSPBP1; HSPBP; HspBP2; hspBP2; HspBP1; HspBP11; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; FES1; FES11; Heat shock protein-binding protein1; Hsp70-interacting protein 1; Hsp70-interacting protein 2; Hsp70 binding protein 1; hsp70-binding protein 2; hsp70 interacting protein; hsp70-interacting protein 1; hsp70-interacting protein 2; heat shock protein-binding protein 1
• Gene ID: 23640
• mRNA Refseq: NM_001130106
• Protein Refseq: NP_001123578
• MIM: 612939
• UniProt ID: Q9NZL4
• Chromosome Location: 19q13.42
• Pathway: Protein processing in endoplasmic reticulum
• Function: enzyme inhibitor activity; protein binding