Recombinant Human HSBP1, GST-tagged

• Cat.No.: HSBP1-13949H
• Product Overview: Recombinant Human HSBP1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-76a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HSBP1 heat shock factor binding protein 1 [ Homo sapiens ]
• Official Symbol: HSBP1
• Synonyms: HSBP1; heat shock factor binding protein 1; heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13; NPC-A-13; DKFZp686D1664; DKFZp686O24200
• Gene ID: 3281
• mRNA Refseq: NM_001537
• Protein Refseq: NP_001528
• MIM: 604553
• UniProt ID: O75506
• Chromosome Location: 16q23.3
• Function: transcription corepressor activity